Evolutionary consequences of antibiotic use for the resistome, mobilome and microbial pangenome

The widespread use and abuse of antibiotic therapy has evolutionary and ecological consequences, some of which are only just beginning to be examined. One well known consequence is the fixation of mutations and lateral gene transfer events that confer antibiotic resistance. Sequential selection even...

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Bibliographic Details
Main Author: Michael R. Gillings
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Microbiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00004/full