Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation

Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation

The monocarbonyl analogue of curcumin (1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one (C1) has been used as a specific activator of the master gene transcription factor EB (TFEB) to correlate the activation of this nuclear factor with the increased activity of lysosomal glycohydrolases and thei...

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Bibliographic Details
Main Authors: Alessandro Magini, Alice Polchi, Danila Di Meo, Sandra Buratta, Elisabetta Chiaradia, Raimondo Germani, Carla Emiliani, Brunella Tancini
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
TFEB
curcumin
curcumin analogue C1
lysosomal glycohydrolases
plasma membrane-associated glycohydrolases
Online Access:http://www.mdpi.com/1422-0067/20/6/1363

Internet

http://www.mdpi.com/1422-0067/20/6/1363

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