Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology

Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology

Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized medicine. Computational models can be used to interpret experimental findings in iPSC-CMs, provide mechanistic insights, and translate these find...

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Bibliographic Details
Main Authors: Chon Lok Lei, Ken Wang, Michael Clerx, Ross H. Johnstone, Maria P. Hortigon-Vinagre, Victor Zamora, Andrew Allan, Godfrey L. Smith, David J. Gavaghan, Gary R. Mirams, Liudmila Polonchuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
cardiomyocytes
stem cell derived
electrophysiology
mathematical model
pharmacology
variability
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00986/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00986/full

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