Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells.

Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells.

Few therapeutic options exist for the highly aggressive triple negative breast cancers (TNBCs). In this study, we report that a contextual synthetic lethality can be achieved both in vitro and in vivo with combined EGFR and PARP inhibition with lapatinib and ABT-888, respectively. The mechanism invo...

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Bibliographic Details
Main Authors: Somaira Nowsheen, Tiffiny Cooper, Jennifer A Stanley, Eddy S Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3469581?pdf=render

Internet

http://europepmc.org/articles/PMC3469581?pdf=render

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