Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

Nfatc2 and Tob1 are intrinsic negative regulators of T cell activation. Nfatc2-deficient and Tob1-deficient T cells show reduced thresholds of activation; however, whether these factors have independent or overlapping roles in negative regulation of T cell responses has not been previously examined....

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Bibliographic Details
Main Authors: Sarah L May, Qing Zhou, Mitzi Lewellen, Cristan M Carter, David Coffey, Steven L Highfill, Christoph M Bucher, Ilze Matise, Herbert C Morse, M Gerard O'Sullivan, Melissa Schutten, Charles Johnson, Donald Bellgrau, Bruce R Blazar, Jaime F Modiano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4063948?pdf=render

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http://europepmc.org/articles/PMC4063948?pdf=render

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