TCR triggering induces the formation of Lck-RACK1-actinin-1 multiprotein network affecting Lck redistribution

TCR triggering induces the formation of Lck-RACK1-actinin-1 multiprotein network affecting Lck redistribution

The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases (SFKs), Lck. Upon TCR triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formation of complex signaling network and cytoskeletal re...

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Bibliographic Details
Main Authors: Ondrej Ballek, Jan Valečka, Martina Dobešová, Adéla Broučková, Jasper Manning, Pavel Řehulka, Jiří Stulík, Dominik Filipp
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
Cytoskeleton
lipid rafts
Lck
TCR triggering
RACK1
α-actinin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00449/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00449/full

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