No evidence of autoimmunity to human OX1 or OX2 orexin receptors in Pandemrix-vaccinated narcoleptic children

Narcolepsy type 1, likely an immune-mediated disease, is characterized by excessive daytime sleepiness and cataplexy. The disease is strongly associated with human leukocyte antigen (HLA) DQB1∗06:02. A significant increase in the incidence of childhood and adolescent narcolepsy was observed after a...

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Bibliographic Details
Main Authors: Krister Melén, Pinja Jalkanen, Jyrki P. Kukkonen, Markku Partinen, Hanna Nohynek, Arja Vuorela, Outi Vaarala, Tobias L. Freitag, Seppo Meri, Ilkka Julkunen
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Translational Autoimmunity
Subjects:
OX1
OX2
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909020300228