Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

Abstract Background Intermediate filament proteins that construct the nuclear lamina of a cell include the Lamin A/C proteins encoded by the LMNA gene, and are implicated in fundamental processes such as nuclear structure, gene expression, and signal transduction. LMNA mutations predominantly affect...

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Bibliographic Details
Main Authors: Halida P. Widyastuti, Trina M. Norden-Krichmar, Anna Grosberg, Michael V. Zaragoza
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Medical Genetics
Subjects:
LMNA gene
Lamin
Laminopathies
Cardiomyopathy
RNA sequencing
IGFBP5 gene
Online Access:http://link.springer.com/article/10.1186/s12881-020-01088-w

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http://link.springer.com/article/10.1186/s12881-020-01088-w

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