Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis

Abstract Phosphorylation of MAP4 (p-MAP4) causes cardiac remodeling, with the cardiac microvascular endothelium being considered a vital mediator of this process. In the current study, we investigated the mechanism underlying p-MAP4 influences on cardiac microvascular density. We firstly confirmed e...

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Bibliographic Details
Main Authors: Yan-hai Feng, Ling-fei Li, Qiong Zhang, Jun-hui Zhang, Yao Huang, Yan-ling Lv, Jie-Zhi Jia, Dongxia Zhang, Jiong-Yu Hu, Yue-Sheng Huang
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00606-w