B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan

Recent studies demonstrated that mutations in B3GNT1, an enzyme proposed to be involved in poly-N-acetyllactosamine synthesis, were causal for congenital muscular dystrophy with hypoglycosylation of α-dystroglycan (secondary dystroglycanopathies). Since defects in the O-mannosylation protein glycosy...

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Bibliographic Details
Main Authors: Jeremy L Praissman, David H Live, Shuo Wang, Annapoorani Ramiah, Zoeisha S Chinoy, Geert-Jan Boons, Kelley W Moremen, Lance Wells
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
congenital muscular dystrophy
O-mannosylation
glycosylation
alpha-dystroglycan
B4GAT1
B3GNT1
Online Access:https://elifesciences.org/articles/03943

Internet

https://elifesciences.org/articles/03943

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