B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan
Recent studies demonstrated that mutations in B3GNT1, an enzyme proposed to be involved in poly-N-acetyllactosamine synthesis, were causal for congenital muscular dystrophy with hypoglycosylation of α-dystroglycan (secondary dystroglycanopathies). Since defects in the O-mannosylation protein glycosy...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/03943 |