Glycolytic Metabolism Is Critical for the Innate Antibacterial Defense in Acute Streptococcus pneumoniae Otitis Media

Glycolytic Metabolism Is Critical for the Innate Antibacterial Defense in Acute Streptococcus pneumoniae Otitis Media

ObjectiveStreptococcus pneumoniae (S.pn) is a common respiratory pathogen and a frequent cause of acute otitis media (AOM) in children. However, little is known about the immunometabolism during AOM. This study was to assess the presence of glucose metabolic reprogramming during AOM and its underlyi...

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Bibliographic Details
Main Authors: Fangmei Fan, Yurong Ma, Rongshuang Ai, Zhiqiang Ding, Dingyi Li, Yiting Zhu, Qian He, Xinxin Zhang, Yilin Dong, Yujuan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
glycolysis
otitis media
innate immunity
neutrophils
hypoxia inducible factor-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.624775/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.624775/full

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