DDB2 regulates DNA replication through PCNA-independent degradation of CDT2

DDB2 regulates DNA replication through PCNA-independent degradation of CDT2

Abstract Background Targeting ubiquitin-dependent proteolysis is one of the strategies in cancer therapy. CRLCDT2 and CRLDDB2 are two key E3 ubiquitin ligases involved in DNA replication and DNA damage repair. But CDT2 and DDB2 are opposite prognostic factors in kinds of cancers, and the underlining...

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Bibliographic Details
Main Authors: Xiaojun Wu, Min Yu, Zhuxia Zhang, Feng Leng, Yue Ma, Ni Xie, Fei Lu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell & Bioscience
Subjects:
DDB2
CDT2
Protein degradation
DNA replication
Ubiquitin ligase
Cancer
Online Access:https://doi.org/10.1186/s13578-021-00540-5

Internet

https://doi.org/10.1186/s13578-021-00540-5

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