Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis.

Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis.

IFN-γ and IL-2 cytokine-profiles define three functional T-cell subsets which may correlate with pathogen load in chronic intracellular infections. We therefore investigated the feasibility of the immunospot platform to rapidly enumerate T-cell subsets by single-cell IFN-γ/IL-2 cytokine-profiling an...

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Bibliographic Details
Main Authors: Rosalyn Casey, Deena Blumenkrantz, Kerry Millington, Damien Montamat-Sicotte, Onn Min Kon, Melissa Wickremasinghe, Samuel Bremang, Murphy Magtoto, Saranya Sridhar, David Connell, Ajit Lalvani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3001879?pdf=render

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http://europepmc.org/articles/PMC3001879?pdf=render

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