Pharmacological Characterization of T-2328, 2-Fluoro-4’-methoxy- 3’-[[[(2S,3S )-2-phenyl-3-piperidinyl]amino]methyl]-[1,1’-biphenyl]-4- carbonitrile Dihydrochloride, as a Brain-Penetrating Antagonist of Tachykinin NK1Receptor
The pharmacological properties of T-2328 were evaluated as an antagonist of the tachykinin neurokinin 1 (NK1) receptor. T-2328 inhibited the specific binding of [3H][Sar9,Met(O2)11]substance P to tachykinin NK1receptors in human lymphoblastic IM9 cells with Kiof 0.08 nM. In the same assay, Kifor apr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2008-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319315440 |