Neuron-specific knockdown of solute carrier protein SLC25A46a induces locomotive defects, an abnormal neuron terminal morphology, learning disability, and shortened lifespan

Neuron-specific knockdown of solute carrier protein SLC25A46a induces locomotive defects, an abnormal neuron terminal morphology, learning disability, and shortened lifespan

Various mutations in the SLC25A46 gene have been reported in mitochondrial diseases that are sometimes classified as type 2 Charcot-Marie-Tooth disease, optic atrophy, and Leigh syndrome. Although human SLC25A46 is a well-known transporter that acts through the mitochondrial outer membrane, the rela...

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Bibliographic Details
Main Authors: Md Saheb Ali, Kojiro Suda, Ryosuke Kowada, Ibuki Ueoka, Hideki Yoshida, Masamitsu Yamaguchi
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:IBRO Reports
Subjects:
dSLC25A46
Drosophila
Neuromuscular junction
Mitochondria
Learning abilities
Online Access:http://www.sciencedirect.com/science/article/pii/S2451830120300054

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http://www.sciencedirect.com/science/article/pii/S2451830120300054

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