Considerations for clinical read alignment and mutational profiling using next-generation sequencing [v2; ref status: indexed, http://f1000r.es/NMpsFc]

Next-generation sequencing technologies are increasingly being applied in clinical settings, however the data are characterized by a range of platform-specific artifacts making downstream analysis problematic and error- prone. One major application of NGS is in the profiling of clinically relevant m...

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Bibliographic Details
Main Author: Gavin R Oliver
Format: Article
Language:English
Published: F1000 Research Ltd 2012-09-01
Series:F1000Research
Subjects:
Online Access:http://f1000research.com/articles/1-2/v2