Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d

Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d

Cas13d is a class 2 type VI-D CRISPR-Cas RNA-guided RNase. Here the authors present the high-resolution crystal structure of the uncultured Ruminococcus sp. Cas13d (UrCas13d)-crRNA complex and by combining structural, mutational and biochemical studies provide mechanistic insights into the CRISPR-Ca...

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Bibliographic Details
Main Authors: Bo Zhang, Yangmiao Ye, Weiwei Ye, Vanja Perčulija, Han Jiang, Yiyang Chen, Yu Li, Jing Chen, Jinying Lin, Siqi Wang, Qi Chen, Yu-San Han, Songying Ouyang
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10507-3

Internet

https://doi.org/10.1038/s41467-019-10507-3

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