The Human Cytomegalovirus UL116 Glycoprotein Is a Chaperone to Control gH-Based Complexes Levels on Virions

The Human Cytomegalovirus UL116 Glycoprotein Is a Chaperone to Control gH-Based Complexes Levels on Virions

Human cytomegalovirus (HCMV) relies in large part upon the viral membrane fusion glycoprotein B and two alternative gH/gL complexes, gH/gL/gO (Trimer) and gH/gL/UL128/UL130/UL131A (Pentamer) to enter into cells. The relative amounts of Trimer and Pentamer vary among HCMV strains and contribute to di...

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Bibliographic Details
Main Authors: Giacomo Vezzani, Diego Amendola, Dong Yu, Sumana Chandramouli, Elisabetta Frigimelica, Domenico Maione, Marcello Merola
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Microbiology
Subjects:
human cytomegalovirus
gH
UL116
pentamer
gH/gL/gO
chaperone
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.630121/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.630121/full

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