Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.

Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.

Accumulating evidence suggests that pathogenic TAR DNA-binding protein (TDP)-43 fragments contain a partial RNA-recognition motif domain 2 (RRM2) in amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration. However, the molecular basis for how this domain links to the conformation and f...

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Bibliographic Details
Main Authors: Akemi Shodai, Akemi Ido, Noriko Fujiwara, Takashi Ayaki, Toshifumi Morimura, Miki Oono, Tsukasa Uchida, Ryosuke Takahashi, Hidefumi Ito, Makoto Urushitani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3530536?pdf=render

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http://europepmc.org/articles/PMC3530536?pdf=render

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