Regulatory switch at the cytoplasmic interface controls TRPV channel gating

Regulatory switch at the cytoplasmic interface controls TRPV channel gating

Temperature-sensitive transient receptor potential vanilloid (thermoTRPV) channels are activated by ligands and heat, and are involved in various physiological processes. ThermoTRPV channels possess a large cytoplasmic ring consisting of N-terminal ankyrin repeat domains (ARD) and C-terminal domains...

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Bibliographic Details
Main Authors: Lejla Zubcevic, William F Borschel, Allen L Hsu, Mario J Borgnia, Seok-Yong Lee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
TRP channel
ion channel
ligand dependent gating
sensitization
cryo-electronmicroscopy
electrophysiology
Online Access:https://elifesciences.org/articles/47746

Internet

https://elifesciences.org/articles/47746

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