Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions

Mutations in the gene encoding LRRK2 (leucine-rich repeat kinase 2) were first identified in 2004 and have since been shown to be the single most common cause of inherited Parkinson's disease. The protein is a large GTP-regulated serine/threonine kinase that additionally contains several protei...

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Bibliographic Details
Main Authors: Elisa Greggio, Mark R Cookson
Format: Article
Language:English
Published: SAGE Publishing 2009-03-01
Series:ASN Neuro
Online Access:https://doi.org/10.1042/AN20090007