The linoleic acid derivative DCP-LA selectively activates PKC-ɛ, possibly binding to the phosphatidylserine binding site

The linoleic acid derivative DCP-LA selectively activates PKC-ɛ, possibly binding to the phosphatidylserine binding site

This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bonds, on protein kinase C (PKC) activity. In the in situ PKC assay with reverse-phase high-performance...

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Bibliographic Details
Main Authors: Takeshi Kanno, Hideyuki Yamamoto, Takahiro Yaguchi, Rika Hi, Takeshi Mukasa, Hirokazu Fujikawa, Tetsu Nagata, Satoshi Yamamoto, Akito Tanaka, Tomoyuki Nishizaki
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Journal of Lipid Research
Subjects:
8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid
protein kinase C-ɛ
protein kinase C-γ
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332132

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http://www.sciencedirect.com/science/article/pii/S0022227520332132

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