CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage

CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage

BackgroundCD47, a glycoprotein on red blood cell membranes, inhibits phagocytosis via interaction with signal regulatory protein α on phagocytes. Our previous research has demonstrated that blocking CD47 accelerates hematoma clearance and reduces brain injury after intracerebral hemorrhage. The curr...

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Bibliographic Details
Main Authors: Fenghui Ye, Ya Hua, Richard F. Keep, Guohua Xi, Hugh J.L. Garton
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
CD47 blocking antibody
Hydrocephalus
Intraventricular hemorrhage
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001339

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http://www.sciencedirect.com/science/article/pii/S0969996121001339

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