Stim and Orai proteins in neuronal Ca2+ signalling and excitability

Stim and Orai proteins in neuronal Ca2+ signalling and excitability

Stim1 and Orai1 are ubiquitous proteins that have long been known to mediate Ca2+ release-activated Ca2+ (CRAC) current (ICRAC) and store-operated Ca2+ entry (SOCE) only in non-excitable cells. SOCE is activated following the depletion of the endogenous Ca2+ stores, which are mainly located within t...

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Bibliographic Details
Main Authors: Francesco eMoccia, Estella eZuccolo, Teresa eSoda, Franco eTanzi, Germano eGuerra, Lisa eMapelli, Francesco eLodola, Egidio eD‘Angelo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neurons
store-operated Ca2+ entry
Ca2+ signaling
Orai1
STIM1
STIM2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00153/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00153/full

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