Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?

We reported that squalamine is a membrane-active molecule that targets the membrane integrity as demonstrated by the ATP release and dye entry. In this context, its activity may depend on the membrane lipid composition. This molecule shows a preserved activity against bacterial pathogens presenting...

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Bibliographic Details
Main Authors: Chanaz Salmi, Celine Loncle, Nicolas Vidal, Yves Letourneux, Jacques Fantini, Marc Maresca, Nadira Taïeb, Jean-Marie Pagès, Jean Michel Brunel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2447875?pdf=render