Early life stress and serotonin transporter gene variation interact to affect the transcription of the glucocorticoid and mineralocorticoid receptors, and the co-chaperone FKBP5, in the adult rat brain.

Early life stress and serotonin transporter gene variation interact to affect the transcription of the glucocorticoid and mineralocorticoid receptors, and the co-chaperone FKBP5, in the adult rat brain.

The short allelic variant of the serotonin transporter (5-HTT) promoter-linked polymorphic region (5-HTTLPR) has been associated with the etiology of major depression by interaction with early life stress (ELS). A frequently observed endophenotype in depression is the abnormal regulation of levels o...

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Bibliographic Details
Main Authors: Rick H. A. Van der Doelen, Francesca eCalabrese, Gianluigi eGuidotti, Bram eGeenen, Marco A. Riva, Tamas eKozicz, Judith R. Homberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Depression
Hippocampus
serotonin transporter
early life stress
Glucocorticoid receptor
mineralocorticoid receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00355/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00355/full

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