An Improved Sequencing-Based Bioinformatics Pipeline to Track the Distribution and Clonal Architecture of Proviral Integration Sites

An Improved Sequencing-Based Bioinformatics Pipeline to Track the Distribution and Clonal Architecture of Proviral Integration Sites

The combined application of linear amplification-mediated PCR (LAM-PCR) protocols with next-generation sequencing (NGS) has had a large impact on our understanding of retroviral pathogenesis. Previously, considerable effort has been expended to optimize NGS methods to explore the genome-wide distrib...

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Bibliographic Details
Main Authors: Nicolas Rosewick, Vincent Hahaut, Keith Durkin, Maria Artesi, Snehal Karpe, Jérôme Wayet, Philip Griebel, Natasa Arsic, Ambroise Marçais, Olivier Hermine, Arsène Burny, Michel Georges, Anne Van den Broeke
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Microbiology
Subjects:
human T-cell leukemia virus type-1
bovine leukemia virus
linear amplification-mediated-PCR
adult T-cell leukemia
retrovirus
clonal architecture
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.587306/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.587306/full

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