Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling

Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling

Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of drugs. Nicotine attenuates the neuroinflammation induced by microglial activation. However, the molecular target(s) underlying anti-inflammatory action of nicotine has not been...

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Bibliographic Details
Main Authors: Hongyuan Li, Yinghua Peng, Cong Lin, Xiaozheng Zhang, Tianshu Zhang, Yibo Wang, Yuanpeng Li, Siru Wu, Hongshuang Wang, Mark R. Hutchinson, Linda R. Watkins, Xiaohui Wang
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:The Innovation
Subjects:
nicotine
cotinine
Toll-like receptor 4
myeloid differentiation protein 2
microglia
molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666675821000369

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http://www.sciencedirect.com/science/article/pii/S2666675821000369

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