Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a

Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a

Gliomas are fast growing and highly invasive brain tumors, characterized by tumor microenvironment acidification that drives glioma cell growth and migration. Channels containing Acid-sensing Ion Channel 1a subunit (ASIC1a) mediate amiloride-sensitive cation influx in late stage glioma cells, but no...

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Bibliographic Details
Main Authors: Maxim Bychkov, Mikhail Shulepko, Dmitry Osmakov, Yaroslav Andreev, Anastasia Sudarikova, Valeria Vasileva, Marat S. Pavlyukov, Yaroslav A. Latyshev, Alexander A. Potapov, Mikhail Kirpichnikov, Zakhar O. Shenkarev, Ekaterina Lyukmanova
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
glioblastoma
astrocytes
mambalgin-2
amiloride-sensitive ion channels
ASIC
cell cycle
Online Access:https://www.mdpi.com/2072-6694/12/7/1837

Internet

https://www.mdpi.com/2072-6694/12/7/1837

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