Chiron approach and the [4 + 2] Diels-Alder cycloaddition of 2-pyrones for the synthesis of cis-(-)-aminoindan-2-ol
A cascade Diels-Alder reaction coupled with an oxidative aromatization reaction was developed and applied to a chiral 2-pyrone for the synthesis of the relevant chiral synthon/chiral auxiliary (-)-cis-aminoindan-2-ol. Chirality and optical purity were provided by the privileged chiron 7,3-LXF.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715621000795 |