Oleanolic Acid-amino Acids Derivatives: Design, Synthesis, and Hepatoprotective Evaluation In Vitro and In Vivo

Oleanolic Acid-amino Acids Derivatives: Design, Synthesis, and Hepatoprotective Evaluation In Vitro and In Vivo

Activated hepatic stellate cells (HSCs) are the main extracellular matrix (ECM)-producing cells in the injured liver and the key mediators of liver fibrosis; they also promote the progression of hepatocellular carcinoma (HCC). In the acidic extracellular microenvironment of HCC, HSCs are activated t...

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Bibliographic Details
Main Authors: Fuhao Chu, Wenxi Zhang, Wenbo Guo, Zhaoyi Wang, Yuqin Yang, Xinyu Zhang, Kang Fang, Mengmeng Yan, Penglong Wang, Haimin Lei
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
OA-amino acids derivatives
hepatoprotective
hepatic stellate cells
apoptosisa
acidic extracellular microenvironment
Online Access:http://www.mdpi.com/1420-3049/23/2/322

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http://www.mdpi.com/1420-3049/23/2/322

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