Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1

Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1

The t(8;21) and inv(16) chromosomal aberrations generate the oncoproteins AML1-ETO (A-E) and CBFβ-SMMHC (C-S). The role of these oncoproteins in acute myeloid leukemia (AML) etiology has been well studied. Conversely, the function of native RUNX1 in promoting A-E- and C-S-mediated leukemias has rem...

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Bibliographic Details
Main Authors: Oren Ben-Ami, Dan Friedman, Dena Leshkowitz, Dalia Goldenberg, Kira Orlovsky, Niv Pencovich, Joseph Lotem, Amos Tanay, Yoram Groner
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713004610

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http://www.sciencedirect.com/science/article/pii/S2211124713004610

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