Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis

Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically compromising lung function and death. However, very little is known about the metabolic alterations of fibroblasts in I...

Full description

Bibliographic Details
Main Authors: Ziwen Wang, Long Chen, Yu Huang, Min Luo, Huilan Wang, Zhongyong Jiang, Jiancheng Zheng, Zeyu Yang, Zelin Chen, Chi Zhang, Lei Long, Yawei Wang, Xueru Li, Fengying Liao, Yibo Gan, Peng Luo, Yunsheng Liu, Yu Wang, XuTan, Ziyuan Zhou, Aihua Zhang, Chunmeng Shi
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
Idiopathic pulmonary fibrosis
Metabolic dysregulation
Succinate
IR-780
Succinate dehydrogenase
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172100241X

Internet

http://www.sciencedirect.com/science/article/pii/S221323172100241X

Similar Items