Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation

Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation

Centrosomes are major microtubule-organizing centers composed of centrioles surrounded by an extensive proteinacious layer called the pericentriolar material (PCM). In Caenorhabditis elegans embryos, the mitotic PCM expands by Polo-like kinase 1 (PLK-1) phosphorylation-accelerated assembly of SPD-5...

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Bibliographic Details
Main Authors: Oliver Wueseke, David Zwicker, Anne Schwager, Yao Liang Wong, Karen Oegema, Frank Jülicher, Anthony A. Hyman, Jeffrey B. Woodruff
Format: Article
Language:English
Published: The Company of Biologists 2016-10-01
Series:Biology Open
Subjects:
C. elegans
PCM
Polo-like kinase
SPD-5
Centrosome
Microtubule
Online Access:http://bio.biologists.org/content/5/10/1431

Internet

http://bio.biologists.org/content/5/10/1431

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