Investigation of the antitumor activity and toxicity of long-circulating and fusogenic liposomes co-encapsulating paclitaxel and doxorubicin in a murine breast cancer animal model

Investigation of the antitumor activity and toxicity of long-circulating and fusogenic liposomes co-encapsulating paclitaxel and doxorubicin in a murine breast cancer animal model

To associate paclitaxel (PTX) with doxorubicin (DXR) is one of the main chemotherapy strategies for breast cancer (BC) management. Despite the high response rates for this combination, it presents a cardiotoxic synergism, attributed to pharmacokinetic interactions between PTX and both DXR and its me...

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Bibliographic Details
Main Authors: Marina Santiago Franco, Marjorie Coimbra Roque, André Luís Branco de Barros, Juliana de Oliveira Silva, Geovanni Dantas Cassali, Mônica Cristina Oliveira
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Co-delivery
Cytotoxicity
Nuclear morphometric analysis
Migration assay
Cardiotoxicity
Antitumor efficacy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218349862

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http://www.sciencedirect.com/science/article/pii/S0753332218349862

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