Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant

Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant

Immune function is altered with increasing age. Infection with cytomegalovirus (CMV) accelerates age-related immunological changes resulting in expanded oligoclonal memory CD8 T cell populations with impaired proliferation, signaling, and cytokine production. As a consequence, elderly CMV seropositi...

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Bibliographic Details
Main Authors: Lauren E. Higdon, Claire E. Gustafson, Xuhuai Ji, Malaya K. Sahoo, Benjamin A. Pinsky, Kenneth B. Margulies, Holden T. Maecker, Jorg Goronzy, Jonathan S. Maltzman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
immunosenescence
cytomegalovirus (CMV)
flow cytometry
Telomere
transplantation immunobiology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.661551/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.661551/full

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