Development and validation of an LC–MS/MS method for quantification of NC-8 in rat plasma and its application to pharmacokinetic studies

Development and validation of an LC–MS/MS method for quantification of NC-8 in rat plasma and its application to pharmacokinetic studies

ent-16-Oxobeyeran-19-N-methylureido (NC-8) is a recently synthesized derivative of isosteviol that showed anti-hepatitis B virus (HBV) activity by disturbing replication and gene expression of the HBV and by inhibiting the host toll-like receptor 2/nuclear factor-κB signaling pathway. To study its p...

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Bibliographic Details
Main Authors: Baxter Hepburn Kachingwe, Yow-Shieng Uang, Tsurng-Juhn Huang, Li-Hsuan Wang, Shwu-Jiuan Lin
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Food and Drug Analysis
Subjects:
Isosteviol derivative
LC–MS/MS
NC-8
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S1021949817301825

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http://www.sciencedirect.com/science/article/pii/S1021949817301825

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