Development and validation of an LC–MS/MS method for quantification of NC-8 in rat plasma and its application to pharmacokinetic studies
ent-16-Oxobeyeran-19-N-methylureido (NC-8) is a recently synthesized derivative of isosteviol that showed anti-hepatitis B virus (HBV) activity by disturbing replication and gene expression of the HBV and by inhibiting the host toll-like receptor 2/nuclear factor-κB signaling pathway. To study its p...
Main Authors: | Baxter Hepburn Kachingwe, Yow-Shieng Uang, Tsurng-Juhn Huang, Li-Hsuan Wang, Shwu-Jiuan Lin |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2018-01-01
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Series: | Journal of Food and Drug Analysis |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1021949817301825 |
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