Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids[S]

Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids[S]

The generation of oxidized phospholipids in lipoproteins has been linked to vascular inflammation in atherosclerotic lesions. Products of phospholipid oxidation increase endothelial activation; however, their effects on macrophages are poorly understood, and it is unclear whether these effects are r...

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Bibliographic Details
Main Authors: Elena Vladykovskaya, Evgeny Ozhegov, J. David Hoetker, Zhengzhi Xie, Yonis Ahmed, Jill Suttles, Sanjay Srivastava, Aruni Bhatnagar, Oleg A. Barski
Format: Article
Language:English
Published: Elsevier 2011-12-01
Series:Journal of Lipid Research
Subjects:
macrophages
cytokines
POVPC
aldose reductase
phospholipase A2
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408259

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http://www.sciencedirect.com/science/article/pii/S0022227520408259

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