Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats

Andrographolide is the most abundant terpenoid of A. paniculata which is used in the treatment of diabetes. In this study, we investigated the effects of A. paniculata extract (APE) and andrographolide on the expression of drug-metabolizing enzymes in rat liver and determined whether modulation of t...

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Main Authors: Haw-Wen Chen, Chin-Shiu Huang, Pei-Fen Liu, Chien-Chun Li, Chiung-Tong Chen, Cheng-Tzu Liu, Jia-Rong Chiang, Hsien-Tsung Yao, Chong-Kuei Lii
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2013/982689