Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice

Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice

The dysregulation of myeloid-derived cell metabolism can drive atherosclerosis. AMP-activated protein kinase (AMPK) controls various aspects of macrophage dynamics and lipid homeostasis, which are important during atherogenesis. Using LysM-Cre to drive the deletion of both the α1 and α2 catalytic su...

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Bibliographic Details
Main Authors: Nicholas D. LeBlond, Peyman Ghorbani, Conor O'Dwyer, Nia Ambursley, Julia R.C. Nunes, Tyler K.T. Smith, Natasha A. Trzaskalski, Erin E. Mulvihill, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Lipid Research
Subjects:
adenosine 5′-monophosphate-activated protein kinase
macrophage
immunometabolism
cholesterol
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520600293

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http://www.sciencedirect.com/science/article/pii/S0022227520600293

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