A Positive Role for PERIOD in Mammalian Circadian Gene Expression

In the current model of the mammalian circadian clock, PERIOD (PER) represses the activity of the circadian transcription factors BMAL1 and CLOCK, either independently or together with CRYPTOCHROME (CRY). Here, we provide evidence that PER has an entirely different function from that reported previo...

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Bibliographic Details
Main Authors: Makoto Akashi, Akihiko Okamoto, Yoshiki Tsuchiya, Takeshi Todo, Eisuke Nishida, Koichi Node
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714002824