Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence

Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence

We show that the C. albicans ureohydrolases arginase (Car1), agmatinase (Agt1), and guanidinobutyrase (Gbu1) can orchestrate an arginase-independent route for polyamine production and that this is important for C. albicans growth and survival in microenvironments of the mammalian host.Amino acid met...

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Bibliographic Details
Main Authors: Katja Schaefer, Jeanette Wagener, Ryan M. Ames, Stella Christou, Donna M. MacCallum, Steven Bates, Neil A. R. Gow
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
candida
arginase
guanidinobutyrase
agmatinase
immunity
morphogenesis
candida albicans
macrophages
Online Access:https://doi.org/10.1128/mBio.01845-20

Internet

https://doi.org/10.1128/mBio.01845-20

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