4-Methylumbelliferone suppresses catabolic activation in anterior cruciate ligament-derived cells via a mechanism independent of hyaluronan inhibition

4-Methylumbelliferone suppresses catabolic activation in anterior cruciate ligament-derived cells via a mechanism independent of hyaluronan inhibition

Abstract Background The anterior cruciate ligament (ACL) has a key role as a dynamic stabilizer of the knee joints, and ACL dysfunction caused by traumatic or degenerative rupture accelerates osteoarthritis progression. Thus, it is important to prevent the degenerative rupture of the ACL. 4-Methylum...

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Bibliographic Details
Main Authors: Masaru Idota, Shinya Ishizuka, Hideki Hiraiwa, Satoshi Yamashita, Hiroki Oba, Yusuke Kawamura, Takefumi Sakaguchi, Takahiro Haga, Takafumi Mizuno, Itaru Kawashima, Kanae Kuriyama, Shiro Imagama
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Anterior cruciate ligament
Osteoarthritis
4-Methylumbelliferone
Hyaluronan
Matrix metalloproteinase
Interleukin-6
Online Access:https://doi.org/10.1186/s13018-021-02637-6

Internet

https://doi.org/10.1186/s13018-021-02637-6

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