WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

Intrinsic resistance to cytotoxic T-lymphocyte (CTL) killing limits responses to immune activating anti-cancer therapies. Here, we established that activation of the G2/M cell cycle checkpoint results in tumor cell cycle pause and protection from granzyme B-induced cell death. This was reversed with...

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Bibliographic Details
Main Authors: Lillian Sun, Ellen Moore, Rose Berman, Paul E. Clavijo, Anthony Saleh, Zhong Chen, Carter Van Waes, John Davies, Jay Friedman, Clint T. Allen
Format: Article
Language:English
Published: Taylor & Francis Group 2018-10-01
Series:OncoImmunology
Subjects:
wee1 kinase
intrinsic resistance
checkpoint inhibition
antigenicity
bystander killing
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1488359

Internet

http://dx.doi.org/10.1080/2162402X.2018.1488359

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