β-cell-specific glucocorticoid reactivation attenuates inflammatory β-cell destruction.

β-cell-specific glucocorticoid reactivation attenuates inflammatory β-cell destruction.

Progression and severity of Type 1 diabetes is dependent upon inflammatory induction of nitric oxide production and consequent pancreatic β-cell damage. Glucocorticoids are highly effective anti-inflammatory agents but have been precluded in type 1 diabetes and in islet transplantation protocols bec...

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Bibliographic Details
Main Authors: XiaoXia eLiu, Sophie eTurban, Roderick N Carter, Shakil eAhmad, Lynne eRamage, Scott P Webster, Brian R Walker, Jonathan eSeckl, Nicholas Michael Morton
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Endocrinology
Subjects:
Anti-Inflammatory Agents
Glucocorticoids
Inflammation
Streptozocin
type 1 diabetes
insulin secretion
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00165/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00165/full

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