Growth Inhibitory Effects of Dipotassium Glycyrrhizinate in Glioblastoma Cell Lines by Targeting MicroRNAs Through the NF-κB Signaling Pathway

Growth Inhibitory Effects of Dipotassium Glycyrrhizinate in Glioblastoma Cell Lines by Targeting MicroRNAs Through the NF-κB Signaling Pathway

It has been shown that nuclear factor kappa-B (NF-κB) is constitutively activated in glioblastoma (GBM), suggesting that the pathway could be a therapeutic target. Glycyrrhetic acid (GA), a compound isolated from licorice (Glycyrrhiza glabra), has been shown to decrease cell viability and increases...

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Bibliographic Details
Main Authors: Gabriel Alves Bonafé, Jéssica Silva dos Santos, Jussara Vaz Ziegler, Kazuo Umezawa, Marcelo Lima Ribeiro, Thalita Rocha, Manoela Marques Ortega
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
glioblastoma
nuclear factor kappa-B
dipotassium glycyrrhizinate
miR16
miR146a
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00216/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00216/full

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