IFI16 knockdown in primary HIV-1 target cells

Summary: IFI16 is an important player of the host intrinsic immune response. Among others, it has been reported to sense intermediate products of HIV-1 reverse transcription in the cytosol and to sequester the transcription factor Sp1 in the nucleus to attenuate viral gene expression. Here, we prese...

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Bibliographic Details
Main Authors: Matteo Bosso, Caterina Prelli Bozzo, Meta Volcic, Frank Kirchhoff
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166720302239