Ageing Fxr deficient mice develop increased energy expenditure, improved glucose control and liver damage resembling NASH.

Ageing Fxr deficient mice develop increased energy expenditure, improved glucose control and liver damage resembling NASH.

Nuclear receptor subfamily 1, group H, member 4 (Nr1h4, FXR) is a bile acid activated nuclear receptor mainly expressed in the liver, intestine, kidney and adrenal glands. Upon activation, the primary function is to suppress cholesterol 7 alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme in the c...

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Bibliographic Details
Main Authors: Mikael Bjursell, Marianne Wedin, Therése Admyre, Majlis Hermansson, Gerhard Böttcher, Melker Göransson, Daniel Lindén, Krister Bamberg, Jan Oscarsson, Mohammad Bohlooly-Y
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3659114?pdf=render

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http://europepmc.org/articles/PMC3659114?pdf=render

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